Microneedling and topical serums powered by stem cell technology are quickly gaining ground as promising strategies for supporting hair growth. With new products, advanced techniques, and ongoing research, many are asking how these interventions compare, whether they can be used together, and what to expect when combining methods like microneedling with innovations such as exosome-rich serums.
Explore expert perspectives shared by Dr. Greg Maguire, NeoGenesis Co-Founder & Chief Scientific Officer, and board-certified dermatologist Dr. Raja Sivamani, addressing core questions about the topical approach to hair health, the science of stem cells and exosomes, and best practices for integrating microneedling.
What’s Next in Cosmetic Solutions for Thinning Hair
Stem cell derived molecules and exosomes are now being incorporated into advanced hair serums. These collections of growth factors and signaling molecules aim to help shift dormant hair follicles out of the resting phase (telogen) and encourage new growth (anagen). Among these, NeoGenesis Hair Thickening Serum couples stem cell exosomes with soluble signaling fractions, designed with the potential to nurture the scalp environment and support the appearance of healthier, fuller-looking hair.
Innovative Topical Approaches to Hair Health
How does NeoGenesis compare to topical minoxidil? Can they be used together?
GREG MAGUIRE: NeoGenesis’ growth factor technology contains a complete set of molecules — both exosomal and soluble fractions—that are released from three types of stem cells critical for driving the hair follicle from the telogen phase to the anagen phase and increasing blood supply to the follicle. Minoxidil, a potent peripheral vasodilator, also works by enhancing blood flow to the follicles. Both can be used together. A small amount of NeoGenesis Hair Thickening Serum should be applied to the scalp to thinly coat the affected area
What is the recommended way to use NeoGenesis for hair support? Should it be applied topically and left on overnight? Can it be used on its own, or is it best combined with other treatments?
GREG MAGUIRE: NeoGenesis Hair Thickening Serum can be used on its own or alongside other treatments, such as microneedling. It may be applied to the affected areas of the scalp at any time of day.
Hair Biology 101
Since hair typically grows about half an inch per month, how is it possible to see a dramatic increase in hair density after just two months of treatment? Is this due to reduced shedding, or is another mechanism involved?
GREG MAGUIRE: Yes, the molecules in NeoGenesis Hair Thickening Serum help shift hair follicles from the telogen phase to the anagen phase and support maintaining the growth phase longer. Users may notice a reduction in shedding as an early benefit, followed over time by the appearance of thicker hair strands and improved hair density.
After seeing visible improvement in hair density, is continued use of Hair Thickening Serum necessary? Will the results be maintained without continued use?
GREG MAGUIRE: After the desired hair results are achieved, a maintenance regimen is necessary. Many users find that applying Hair Thickening Serum once daily—or in some cases, every other day—helps sustain its effectiveness over the long term.
The Role of Microneedling Strategies for Thinning Hair
Do you use microneedling for hair restoration?
RAJA SIVAMANI: Needle based stimulation of hair growth has been around for hundreds of years and has been used previously in both Ayurvedic and Chinese medicine. With technological advances, microneedles have been studied and can stimulate hair growth through micro-injury of the skin and increased local blood flow. Micro-injury of the skin can be performed with microneedles or with laser-based therapies through the use of the Er:YAG laser. Some companies even have laser delivery instruments in the shape of combs.
Yes, microneedling is utilized in hair restoration treatments. By creating micro-injuries in the scalp, it stimulates blood flow and can enhance the absorption of topical treatments like minoxidil and NeoGenesis Hair Thickening Serum. Studies have shown that combining microneedling with other therapies can improve outcomes in conditions like androgenetic alopecia.
Building a Smarter Hair Support Strategy
Today’s innovations in hair restoration go beyond one-size-fits-all solutions. With targeted topicals powered by stem cell derived molecules and exosomes, and procedures like microneedling enhancing absorption and stimulation, you now have access to more sophisticated ways to support healthier, fuller hair.
Understanding how these treatments work—both individually and together—can help you create a personalized routine that aligns with your goals. For those with existing scalp conditions or using prescription therapies, it’s important to assess safety and compatibility before adding microneedling or topical products like exosome serums.
For a deeper look into the science behind microneedling and stem cell derived exosome therapies, we invite you to review this published study featuring the use of NeoGenesis Hair Thickening Serum in combination with microneedling. The findings offer valuable insights into how these modalities may work together to support hair health and density.
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