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The Ultimate Q&A Guide to Microneedling + Laser Therapy

The Ultimate Q&A Guide to Microneedling + Laser Therapy

Procedures like microneedling and laser therapies are changing how we approach skin health. These techniques, especially when combined with innovative topical products containing stem cells and exosomes, are generating real interest among patients and clinicians seeking better outcomes and safer post-procedure experiences.

In this Q+A, we feature insights from Dr. Greg Maguire, NeoGenesis Co-Founder & Chief Scientific Officer, and board-certified dermatologist Dr. Raja Sivamani. Together, they provide candid, evidence-based answers to common questions about microneedling, laser treatments, and the role of Recovery serum in post procedure care. 

Microneedling Safety & Best Practices

Is microneedling safe for everyone? Are there any specific conditions or groups you would not recommend this procedure to?

RAJA SIVAMANI: Yes, typically, it is safe for everyone when it is just the microneedling without radiofrequency. However, patients with a history of keloidal scarring may be at increased risk and should discuss this with their clinician. When radiofrequency is added, the intensity of the radiofrequency can lead to side effects in those with darker skin pigmentation.

Can patients with a history of mild to moderate psoriasis safely undergo microneedling and laser procedures?

RAJA SIVAMANI: Microneedling and laser treatments can be used cautiously in patients with psoriasis. It is important to avoid actively inflamed areas, as treatment may trigger a psoriasis flare, particularly in sensitive areas like the neck.

What’s the typical needle depth used during microneedling? Does this depth vary between different brands?

RAJA SIVAMANI: Microneedling pen devices typically offer adjustable needle depths ranging from 0.5 mm to 2.5 mm. However, the true depth of penetration will depend on other factors such as how firmly the practitioner pushes down on the device when administering the treatment. Depths between 0.5 mm and 1 mm are often used to enhance topical product absorption and address uneven pigmentation, while depths of 1.5 mm to 2.5 mm are generally better suited for acne scar treatments.

Since deep microneedling can increase the risk of hyperpigmentation, is there a recommended maximum needle depth to reduce this risk?

RAJA SIVAMANI: Deeper microneedling may increase the risk of hyperpigmentation, though this is not guaranteed and can vary depending on the background level of pigmentation of the patient. Individuals with darker skin tones may have a slightly higher risk, but this can be mitigated with appropriate topical therapies applied before and after treatment. Additionally, sun protection is essential to minimize treatment-related side effects.

Is microneedling safe on the lips?

Microneedling for Acne Scarring

RAJA SIVAMANI: Microneedling on the lips has greater risk due to the delicate nature of the lips. If microneedling of the lips are performed, shallower treatments should be used.

Can superficial microneedling benefit patients with scleroderma?

RAJA SIVAMANI: The scarring caused by scleroderma is typically deep, and microneedling is unlikely to be helpful.

Does microcurrent enhance topical delivery after microneedling?

RAJA SIVAMANI: Microcurrents may not be necessary to enhance topical penetration after microneedling. Since microneedling creates channels in the skin, it already facilitates easier absorption of topical products. It remains unclear whether microcurrent provides any additional benefit.

Demystifying Recovery Serum & Exosomes

How does Recovery serum maintain exosome efficacy when it is not ‘frozen’ but is in a serum that is at room temperature?

GREG MAGUIRE: Exosomes are naturally released from cells and evolved in nature to have very stable physicochemical properties in natural biological systems, including a lipid bilayer structure that is about 50-80 nanometers in diameter. Their stability allows them to exist in a wide range of environments—including blood, tissues, milk, grape juice, the gut, and other biological fluids—across various temperatures and pH levels. Exosomes integrity is susceptible to high shear forces, something they are not subject to in their natural environment of the body; therefore, our formulations and manufacturing processes never include shearing the exosomes. Antimicrobial preservatives are used to prevent contamination of the solution containing the exosomes.

Can you use Recovery serum after photodynamic therapy?

GREG MAGUIRE: Photodynamic therapy (PDT) is a two-stage treatment that combines a photosensitizing agent with light energy. When activated by light, the photosensitizer produces reactive oxygen species (ROS), such as hydrogen peroxide (H₂O₂), which target and destroy cancerous and precancerous cells. ROS levels typically peak about two hours after light activation, at which point cell death occurs. Because Recovery contains ingredients that support the skin’s natural healing environment, we recommend applying it after the active phase of treatment is complete to help support skin renewal.

NeoGenesis Recovery Serum for Microneedling and Laser

Should Recovery serum be applied immediately after a professional procedure, or is it better to wait a few hours?

GREG MAGUIRE: Recovery can be used before, to precondition the skin, and after a procedure to help calm irritation, support the skin’s natural renewal process, and help minimize the appearance of fibrotic scarring, thus optimizing post-procedure results.

Are NeoGenesis products, like Recovery serum, helpful after Efudex treatment?

GREG MAGUIRE: Yes, NeoGenesis Recovery serum does not interfere with the mechanism of action of 5-FU (fluorouracil), which works by inhibiting DNA synthesis. Recovery is designed to support the skin’s natural healing process and may help reduce the appearance of redness and irritation commonly associated with topical treatments.

Has Recovery serum proven useful after ED&C procedures, especially on areas like the upper back, shoulders, or chest that are more prone to hypertrophic scarring?

GREG MAGUIRE: Although there is no specific data for use after Electrodesiccation and Curettage (ED&C), Recovery serum contains stem cell released molecules that are intended to support skin health. These ingredients are commonly associated with reducing inflammation, supporting collagen production, and helping maintain a healthy skin environment after burns and skin injuries. Recovery may be beneficial as part of a post-procedure skincare routine.

Why Aftercare Matters: Maximizing Outcomes

Effective post-procedure care is as critical as the procedure itself in determining patient satisfaction and clinical outcomes. Whether you are considering microneedling, laser treatments, or ongoing topical therapies, understanding patient suitability, proper procedural technique, and smart aftercare choices (like targeted serums with stem cell derived molecules and exosomes) ensures better long-term results.

Discover how NeoGenesis’ advanced skincare solutions and protocols can enhance your microneedling results — learn more about supporting optimal skin recovery today.

Ready to boost your microneedling results? Explore NeoGenesis’ advanced skincare solutions and protocols — Learn More Here.

 

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(858) 751-4714
www.NeoGenesis.com
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